I've had VFIO passthrough setup on a NixOS host before without issue. While this guide isn't the one I followed it is an accurate and good guide.
bzLem0n
That sounds good and it's hard to go wrong adding bacon to anything.
The only game soundtrack I ever recall make a point of listening to is from Faster Than Light, it's some really good ambient music.
All I waited for was a decent deal on a 1TB ssd and it went smooth, aside from not plugging the battery back in fully the first time. I cloned as I didn't want to bother with setup again.
I really enjoy using NixOS as it is good at what it does, declarative system configuration, but it does have issues that can prevent people from using it. It's great if you want to put the configuration for all your computers in one git repo but that configuration is in the Nix language so you will eventually need to become familiar with the Nix language. The main issues are that the documentation needs work and understanding the difference between the Nix operating system, the Nix language, and the Nix package collection as the more you use NixOS the more familiar you will need to be with each.
That said, I find it worth learning and recommend some of the following resources for NixOS.
MyNixOS for graphical configuration management. See my configs there.
NixOS Wiki for the best collection of NixOS documentation. I've found this collection of people's configurations to be very useful for inspiration.
The manual pages for the Nix language, Nix packages, and NixOS.
NixOS on everything but my Steam Deck which is running SteamOS.
You should put the aliases in
/etc/profile
or create a file in/etc/profile.d/
for them. Most modern shells will source /etc/profile which in turn sources the files in /etc/profile.d/, so that's the best spot for things like aliases for all users. See the Arch Wiki page Command-line shell, specifically sections 4 and 5.