I had issues with Dishonored when it launched years ago also. Have you updated your graphics drivers or checked the Steam Community page for troubleshooting as well?
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Looking at the community page there are definitely other people with the same or similar issues. No unique solutions though. Just the things I've already tried (which I list in a different comment).
This is so depressing.
When a program fails to launch, you probably want to use windows Event Viewer to look through the application logs to find out why.
You may also try using steam to verify the game files as well.
I will check out that event viewer. I had verified the game files though yes.
Another common issue with newly built computers is that people often plug their monitor into the integrated video of their motherboard rather than their graphics card.
If this is an issue exclusive to Dishonored, then disregard. Otherwise, you might just double check where your monitor is plugged.
I see from your notes that you disabled the onboard video, so that's probably not the use in this case.
Best of luck! Hope you can figure this one out.
Monitor is plugged into graphics card.
For those playing at home I have uninstalled, reinstalled, verified integrity of files, tried all combinations of running steam and dishonored as admin, there are no events in the event viewer, I have disabled onboard graphics, I tried running it off of a different hard drive, I tried starting it in windowed mode, I've tried compatibility modes for win 7 and 8, I've updated my graphics card driver, and there are no windows updates to apply.
I'm basically out of options over here. Looks like I don't get to play this game.
Does it just close or is there a very low res splash screen? I believe these are two issues I've had. The first was resolved by unplugging my second monitor and setting the desktop resolution to 1080p from 4k, the second was resolved by just waiting it out for probably over 15 minutes!