David Sinclair is an interesting person. I've seen him present his research in a professional setting and he does some really interesting science. He is also very enthusiastic at selling his story.

There's likely no amount of supplement and drug cocktails that will undo the damage of a sedentary lifestyle and poor diet. Best case scenario is this research could be on to something that significantly augments a healthy lifestyle, or worse case it could be wasting a lot of money on something that potentially ends up being harmful a few decades from now.

I've looked at the list of supplements and drugs Dr. Sinclair takes and there is mechanistic rationale from cell culture and animal experiments behind the ones I'm most familiar with. But it is a big leap to go from cell culture and animal models to human health on a much longer time span. The clinical trials needed to really demonstrate a lot of these claims are incredibly expensive and would take decades. Drug companies in the anti-aging field tend to focus on older patients to start with and earlier endpoints like lower cancer, Alzheimer's, or heart disease incidence. They also tend to be funded by silicon valley tech executives.