Gaming

Not even close. I'm playing it right now, well into act 2, and while it is THE ultimate example of what a cRPG should be, that doesn't necessarily mean the breadth and scope would work in other genres. You're WAY overestimating the impact this is having on the gaming industry, and that's evidenced by how other developers are responding to it.
Also. I've played through all the Mass Effects (even Andromeda, which I actually enjoyed more) and to say that it was industry-defining is a fanboy take. Full stop. From where I'm sitting ME1 did not introduce anything groundbreaking that hadn't been done already by that point, and to be honest the early Fallout games had way more gravity when it came to choices and decision-making. I'd say of games in that era, the original Borderlands was more ground-breaking given it kind of kickstarted the looter-shooter genre, and that's a stretch.