this post was submitted on 16 Oct 2024
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I'm currently writing a small literature review on tgf-b and SMAD signalling in cancer for uni rn
And I'm really confused why this one paper's talking about how miR-520h induces the tgf-b/smad7 pathway but also binds to and suppresses smad7
Like why on earth is it activating the tgf-b/smad7 pathway, a pathway that stops stuff like the epithelial mesenchynal transition, if it's just going to bind to smad7 anyway???
Worst thing is, I can't find any other papers on why this actually happens
I swear I'm just dumb at times ;-;
I'll take two scoops
Ah, yes. Of course. I understand your frustration entirely because of my deep understanding of the specific situation.
Would a list of tools and search engines be helpful?
That would be very helpful 🥴
Sorry, better late than never. Will dm you. Others are welcome too.
Cell signalling pathways was the worst part of microbial genetics for me. Luckily I don't have to deal with that anymore as my day to day is digital PCR and NGS.