You're right, and an upvote for you. I've seen colleagues who encounter a 90% drop in efficacy when making the leap to Phase 1 trials (and this is excluding safety concerns!).
It is rigorous and thank everything the Process is put in place. But I specifically used Oxycontin as an example for a pertinent reason. Rigour isn't applied to everyone equally, and I think that itself underscores a need to think critically.
Who the fuck downvoted you? I've never encountered anyone bullying fat people in the gym before. Maybe these memers should actually go visit a gym.