I don't relate with masculine characters at all. No idea why as I don't identify as a woman. I have very little association or ownership of my gender.
Also character creators traditionally don't have a ton of options beyond the binary. Hair, pronoun options tend to be most of the extent.
Also feminine bodies tend to be more interesting. More curves and interesting shapes while a lot of masculine bodies are rendered as blocky.
I play in 2 games and run 1. As a player I play both characters who share my gender and one that doesn't. At the table I run there's a guy who plays a woman, and used to be another.
It's never caused issues or confusion. So for anyone interested in playing like this, feel free to do so! For pronouns I've also found success in referring to characters instead of players with names unless explicitly talking to the player, but that's easier as a GM.