I'm really sorry to hear that you're struggling with this, but please don't do MDMA, speed or cocaine to self-medicate your depression. They will make things worse, especially MDMA, being low serotonin is no joke and if you're already suffering from depression then you're asking for trouble, plus it can be really dangerous to use MDMA when you're taking anti-depressants.
You could try mushrooms or LSD, either micro or macrodose. I find that both can have the same effect but if you've done shrooms or acid before and can handle a macrodose I would recommend trying that. Personally I find that I feel much better for weeks after doing a good dose of shrooms, no need to microdose all the time.
The trip can be a very painful and traumatic experience but I find that no matter how the trip went, I come out of it feeling much better. I find myself no longer stuck in a negative thought loop and am able to view things from different perspectives which can be a very powerful thing when you're dealing with depression.