Longevity

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TERT activation targets DNA methylation and multiple aging hallmarks (www.sciencedirect.com)

submitted 4 months ago by toast@retrolemmy.com to c/longevity@mander.xyz

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TAC promoted tissue rejuvenation, including new neuron formation, and alleviated multiple aging hallmarks in aged mice, revealing the regenerative potential of adult tissues through physiological TERT activation.

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[–] JoMomma@lemm.ee 3 points 4 months ago (2 children)

Are they intentionally not naming or describing the TAC?

[–] Sal@mander.xyz 2 points 4 months ago

The structure is shown in the full text:

[–] toast@retrolemmy.com 1 points 4 months ago

It really seems like it.

[–] Sal@mander.xyz 2 points 4 months ago (1 children)

This work using high-throughput combinatorial chemistry to find molecules to stop/revert aging is amazing. I have been looking it in the past few days. The authors screened 653,000 different compounds, I am very curious about how expensive this screening was.

I was not aware of DePinho but I am familiar with Schultz's work. I thought that would get a Nobel prize for his work on non-canonical amino acids, but he hasn't yet. I am now placing my bets, Ronald DePinho and Peter G. Schultz will win a Nobel prize.

[–] toast@retrolemmy.com 2 points 4 months ago

Certainly an interesting study. I hope we get to hear more about it soon, and hope their work is followed up on