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Big brain tech dude got yet another clueless take over at HackerNews etc? Here's the place to vent. Orange site, VC foolishness, all welcome.

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Stubsack: weekly thread for sneers not worth an entire post, week ending Sunday 2 June 2024 (awful.systems)

submitted 6 months ago by froztbyte@awful.systems to c/techtakes@awful.systems

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Have a sneer percolating in your system but not enough time/energy to make a whole post about it? Go forth and be mid!

Any awful.systems sub may be subsneered in this subthread, techtakes or no.

If your sneer seems higher quality than you thought, feel free to cut’n’paste it into its own post, there’s no quota for posting and the bar really isn’t that high

The post Xitter web has spawned soo many “esoteric” right wing freaks, but there’s no appropriate sneer-space for them. I’m talking redscare-ish, reality challenged “culture critics” who write about everything but understand nothing. I’m talking about reply-guys who make the same 6 tweets about the same 3 subjects. They’re inescapable at this point, yet I don’t see them mocked (as much as they should be)
Like, there was one dude a while back who insisted that women couldn’t be surgeons because they didn’t believe in the moon or in stars? I think each and every one of these guys is uniquely fucked up and if I can’t escape them, I would love to sneer at them.

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[–] skillissuer@discuss.tchncs.de 3 points 5 months ago (2 children)

the problem is that trials are pretty expensive, we're talking something about billion dollars per compound range for the entire thing from phase 1 to market, and even then some 85%+ fail. (of course phase 1 failure is cheaper than phase 3 failure) at this point all IP is owned by bean counters backed by VCs or one of few mammoth biopharma gigacorporations

i understand that a lots of new drugs is developed this way: an sfba startup gets funded, does a thing, sucks VCs off for few tens of millions of dollars, tries to push something to phase 1 and then either doesn't that and collapses or does that, sells IP to someone bigger, and also collapses (because they fired biologists to hire compliance), or if they don't collapse, they repeat until they do, accumulating half-baked IP along the way

btw this is part of the reason why antibodies are such a big thing, small changes can keep these things patented basically indefinitely and at the same time these are hard enough to make that generics will be pretty hard to impossible. one sane solution would be to try some state-funded research in this area

[–] gerikson@awful.systems 5 points 5 months ago

Yeah I'm kinda familiar with the realities of drug development and testing, which is why I prefaced my comments with the solution being essentially magic. If we find hte magic bullet for cancer I expect it will be a slow grind and a lot of trial and error, so the wealth will be diluted across many entities. Not to mention the current business of cancer care might try hard to stop it...

[–] skillissuer@discuss.tchncs.de 3 points 5 months ago

in american context specifically, from what i understand, the biggest financial black hole are the intermediaries, all these motherfuckers whose job is to say that no, you won't get it paid out of insurance