this post was submitted on 25 Feb 2024
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The lethal doses of 55 substances (infosec.pub)
submitted 8 months ago by Ninjazzon@infosec.pub to c/coolguides@lemmy.ca
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[–] Taniwha420@lemmy.world 6 points 8 months ago (2 children)

Yes, I came here for this conversation. What's the ratio of effective dose to LD50 again, because that's typically what matters. That's where cannabis and ethanol are in totally different categories. And how high do you need to get before dying from LSD?

[–] Pipoca@lemmy.world 4 points 8 months ago (1 children)

16.5 mg is 16500 μg. So a 70kg person would need over 1 million μg.

According to https://www.trippingly.net/lsd/the-lsd-dosage-guide, 25 μg is where visual effects start.

700 to 1000 μg. Full out-of-body experiences. Synesthesia more likely. Religious imagery often strong. Entire loss of rationality, lack of ability to walk or interact in any meaningful way.

1500 μgs+ Experiences may be similar to DMT but extended. Basic body functions are challenging. Vision is consumed by hallucinations. No sense of self remains. Audio hallucinations may be strong. Standard reality no longer applies. Merging with objects likely. No type of rational thought left.

A deadly dose is around 800x higher than that. You wouldn't be as high as a kite. You'd be as high as Voyager one.

[–] smegforbrains@lemmy.ml 3 points 8 months ago

The data about LSD lethality in humans is sparse at best it seems: https://www.healthline.com/health/substance-use/can-you-overdose-on-lsd#risk-of-death

[–] sicarius@lemmy.world 2 points 8 months ago

That dose of 16.5mg/kg ld50 is for rats.
Mice is lower at 0.3mg/kg.
There have been no know deaths from humans overdosing on lsd, even when people have taken ridiculously high amounts by mistaking it for cocaine and railing lines of it up their nose.
Sure, a little coma, hypERthermia and light gastric bleeding but nothing a short stint in the hospital didn't sort em out with no lasting effects.