this post was submitted on 19 Jun 2023
31 points (100.0% liked)
Science
3179 readers
14 users here now
General discussions about "science" itself
Be sure to also check out these other Fediverse science communities:
founded 2 years ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
view the rest of the comments
I’m not quite sure I understand what “social reward learning period” means exactly after reading through that paper. Can anyone help explain that in more concrete terms?
In the paper, they state that the 'social reward learning period' is a critical period that they described in their previous paper:
Their previous paper that they cite is the following:
Nardou, Romain, et al. "Oxytocin-dependent reopening of a social reward learning critical period with MDMA." Nature 569.7754 (2019): 116-120. (Scihub)
Here they are more specific about what they mean with a 'critical period':
And they point out that the term 'social reward learning' is described in the following paper:
Dölen, Gül, et al. "Social reward requires coordinated activity of nucleus accumbens oxytocin and serotonin." Nature 501.7466 (2013): 179-184. (Scihub)
From this paper, the difinition is:
So, putting it all together:
A social interaction can in itself produce feeling of reward. The ability to experience social interaction as a reward is not 'innate', but rather an acquired ability that requires the brain to undergo certain plastic transformations. There is a period during the early development of an animal in which the region of the brain that controls the social reward pathway is highly plastic and responsive to stimuli. This period is considered a critical period, because it is during this stage that the plastic brain can develop a topology that allows the animal to feel more or less strongly rewarded by social interactions. After the critical period of development has passed, this brain region is no longer very plastic, and so the ability of the animal to experience social interactions as a reward cannot easily be changed over time.
In this study, they show that it is possible to move the brain back towards the plastic state that is present during the critical development period, potentially allowing the mature animal to develop or increase its capacity to experience social interactions as a reward.
Amazing. Thank you so much for the deep research and citations.
In other words, psychedelics seems to have a pro social effect on the mice? That’s very interesting. Especially in the world when we are increasingly trained to be anti-social.
No problem!
The psychedelic appears to bring the brain regions that are involved in pro-social effects into a more flexible state. But they do not guarantee a pro-social effect.
If you provide the right stimulus during the time that the brain is flexible, this can have a pro-social effect on the mice. But in principle it is also possible to apply the "wrong" stimulus and restructure the brain into a more anti-social state.
Psychedelics are on the path of potentially becoming a very important class of medicines because they appear to have the ability to allow the brain's neural pathways to be re-wired in a relatively short period of time. Psychedelic therapies are an interesting combination of the psychiatrist and the classical psychotherapist - the idea is that the person is given a psychedelic drug, bringing the brain into a flexible state, and the therapist attempts to provide the correct stimuli during this state to strengthen certain neural pathways associated with processes such as the reward cycles.
The value of these therapies have been recognized by our ancestors for a very long time, but only recently have they begun to be taken seriously by the scientific and medical fields. Traditionally, the stimuli are provided via set and setting and guided meditations - but the scientific field has not yet gotten that far yet. Scientists and doctors work with a much higher standard than the shamans from the past when it comes to showing that things actually work. We can't just assume that the way our ancestors did it was optimal. This is becoming an active field of research, and there is still a lot to be tested....