I'm not familiar with Nobara, but I can at least show how I would install pyUSB for use in Debian:

If you follow the instructions exactly as in the readme, it will error:

$ pip install pyusb
error: externally-managed-environment

× This environment is externally managed
╰─> To install Python packages system-wide, try apt install
    python3-xyz, where xyz is the package you are trying to
    install.
    
    If you wish to install a non-Debian-packaged Python package,
    create a virtual environment using python3 -m venv path/to/venv.
    Then use path/to/venv/bin/python and path/to/venv/bin/pip. Make
    sure you have python3-full installed.
    
    If you wish to install a non-Debian packaged Python application,
    it may be easiest to use pipx install xyz, which will manage a
    virtual environment for you. Make sure you have pipx installed.
    
    See /usr/share/doc/python3.11/README.venv for more information.

note: If you believe this is a mistake, please contact your Python installation or OS distribution provider. You can override this, at the risk of breaking your Python installation or OS, by passing --break-system-packages.
hint: See PEP 668 for the detailed specification.

Instead, I would create a virtual environment (I'm using virtualenv instead of venv)

$ virtualenv unihub_test

Then activate the environment and run the install with pip

$ source ~/unihub_test/bin/activate
(unihub_test) $ pip install pyusb
Collecting pyusb
  Using cached pyusb-1.2.1-py3-none-any.whl.metadata (2.2 kB)
Using cached pyusb-1.2.1-py3-none-any.whl (58 kB)
Installing collected packages: pyusb
Successfully installed pyusb-1.2.1

(unihub_test) $ python3
>>> import usb #this should not error
>>> exit()
(unihub_test) $ deactivate
$ 

Without the actual hub, that's as far as I can go I think - but maybe this will help give you some options and documentation to explore!