this post was submitted on 12 Jul 2024
138 points (97.9% liked)

science

14762 readers
554 users here now

A community to post scientific articles, news, and civil discussion.

rule #1: be kind

<--- rules currently under construction, see current pinned post.

2024-11-11

founded 1 year ago
MODERATORS
you are viewing a single comment's thread
view the rest of the comments
[–] witty_username@feddit.nl 21 points 4 months ago (2 children)

I'm convinced that the Alzheimer's field is one of the areas of research that will be looked back upon with disillusionment.
Tau tangles and beta plaques have been fiercely and dogmatically pursued as causes and therapeutic targets of Alzheimer's disease. However, it is becoming increasingly clear that these aggregations are likely a consequence of the disease that does not necessarily present an avenue for therapy. I.e. the harmful part of the disease probably acts upstream of or in parallel to the accumulation of the tau and beta aggregations

[–] Snowflake@sh.itjust.works 25 points 4 months ago (1 children)

All because Sylvain Lesné and team published a fraudulent research paper in 2006. The field has possibly lost a decade of time and money.

[–] amenji@programming.dev 8 points 4 months ago

TIL. Damn.

Reminds me of the how early the covid policies were based on age-old misconceptions about aerosols.

[–] joelthelion@lemmy.world 2 points 4 months ago

How do you explain that amyloid-targetting therapies are seeing some success, even if limited?