The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
hun you're a kbinaut, not a sh.itjust.works user. You'd be unaffected by their defederating if it happens.