The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
I personally think defederating shouldn't happen generally. I'd rather there be customizable user filters for either words, subjects, etc.
Like I'm not really into their content (or that of some other instances) but defederating at an instance level is kind of a giant hammer for the few folks who may (for better or worse) be interested in both instances.
The paradox of tolerance.